vIndianz.com (24 Nov, 2009) — Many people who are fat or obese develop insulin resistance and type 2 diabetes at some phase in their lives. A European research team has currently discovered that obese people have great amounts of the molecule CXCL5, formed by certain cells in fatty tissue.
The major risk factors for type 2 diabetes are obesity and a deskbound lifestyle. The biomedical community is well-known for many years that substances formed by fatty tissue are accountable for the association between obesity and diabetes. “Chronic inflammation of the adipose tissue, which is characteristic of obese people, is a crucial stage in the development of insulin resistence and type 2 diabetes”, Lluis Fajas, lead author of the study and a researcher at the Institute of Health and Medical Research (Inserm) in France, told SINC.
The outcome of this fresh study show that serum levels of a chemokine molecule called CXCL5, formed by definite adipose tissue cells, come out at much high levels in the tissues of obese people than in those of persons with average weight. This has helped Lluis Fajas’s research team to come to a biomedically applicable conclusion: “The CXCL5 molecule helps cause insulin resistance and type 2 diabetes”.
The most significant ingredient of this study, published in the journal Cell Metabolism, is the finding that an experimental treatment aimed at inhibiting the action of CXCL5 can assist to shield obese mice from developing type 2 diabetes. “If these studies can be established in humans, this treatment would signify a primary improvement in the quality of life of obese individuals”, the researcher concludes.
Further Reading- Mutant Gene Found in Many With Type 2 Diabetes – WebMD
- Molecular switch that triggers allergic response in humans identified
- Diabetics could soon ‘grow their own insulin’ – Daily Mail
- Metformin Found to be Superior Diabetes Drug – ThirdAge
- Time for Clinically Relevant Comparative Effectiveness Studies in Type 2 Diabetes – Annals of Internal Medicine
- Mutant Gene Found in Many With Type 2 Diabetes – WebMD
- Glaxo, Tolerx diabetes drug fails in study – BusinessWeek
- New Drug May Trim Insulin Injections to Just 3 a Week – BusinessWeek
- Diabetes Often Not Diagnosed or Treated Properly – BusinessWeek
- Prescription for Type 2 Diabetes: Cardio Plus Weights – TIME
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